李德富，男，教授，beat365黨委副書記兼紀(jì)委書記。全國普通高等學(xué)校本科教育教學(xué)評(píng)估專家，國家科技專家?guī)鞂＜?，中國高校?chuàng)新創(chuàng)業(yè)教育研究中心專家?guī)鞂＜?，中國化工學(xué)會(huì)醫(yī)藥化工專委會(huì)委員，四川省學(xué)術(shù)和技術(shù)帶頭人后備人選，四川省科青聯(lián)常務(wù)理事，四川省“互聯(lián)網(wǎng)+”學(xué)生創(chuàng)新創(chuàng)業(yè)大賽優(yōu)秀創(chuàng)新創(chuàng)業(yè)導(dǎo)師，成渝地區(qū)雙城經(jīng)濟(jì)圈科技創(chuàng)新聯(lián)盟咨詢專家。四川大學(xué)“化工之星”優(yōu)秀青年人才入選者，四川大學(xué)優(yōu)秀青年學(xué)者科研基金獲得者。主要從事生物質(zhì)化學(xué)與材料等方面的研究工作，在多糖基食品殺菌劑和包裝膜、新型骨缺損修復(fù)屏障膜等方面開展了大量原創(chuàng)性的工作。主持國家自然科學(xué)基金、省部級(jí)科技項(xiàng)目和企業(yè)合作課題10余項(xiàng)；在Advanced Healthcare Materials、ACS Applied Materials & Interfaces、ACS Sustainable Chemistry and Engineering、Carbohydrate Polymers、FoodChemistry等國內(nèi)外學(xué)術(shù)期刊發(fā)表論文80余篇，他引2000余次，ESI高被引論文3篇；授權(quán)發(fā)明專利20余項(xiàng)，已成功轉(zhuǎn)化3項(xiàng)。
郵箱：lidefu@scu.edu.cn
一、教育和工作經(jīng)歷：
2001/09－2005/07，四川大學(xué)，beat365制藥與生物工程系，大學(xué)本科
2005/09－2010/07，四川大學(xué)，beat365制藥與生物工程系，碩博連讀研究生
2010/07－2014/06，四川大學(xué)，beat365制藥與生物工程系，講師
2013/12－至今 四川大學(xué)，beat365生物化工專業(yè)，碩士生導(dǎo)師
2014/07－2021/09 四川大學(xué)，beat365制藥與生物工程系，副教授
2021/09－至今 四川大學(xué)，beat365制藥與生物工程系，教授
二、社會(huì)工作：
2012/08－2013/07，江蘇省委組織部“科技鎮(zhèn)長(zhǎng)團(tuán)”成員，江蘇省鎮(zhèn)江市丹徒區(qū)宜城街道黨工委，副書記
三、研究方向：
天然高分子的化學(xué)改性；生物質(zhì)化學(xué)與材料
四、中國發(fā)明專利：
1.一種功能性明膠粉條及其制備方法.專利號(hào)：ZL201010119060.7
2.一種納米復(fù)合材料中納米粘土的冷凍分散方法.專利號(hào)：ZL201110130461.7
3.一種酚酸類改性膠原蛋白面膜及其制備方法.專利號(hào)：ZL201110309522.6
4.一種II型膠原和硫酸軟骨素的綜合提取工藝.專利號(hào)：ZL201210196922.5
5.一種廢水中陽離子染料吸附劑及其制備方法.專利號(hào)：ZL201210482472.6
6.一種明膠基納米復(fù)合材料及其制備方法.專利號(hào)：ZL201210528098.9
7.一種功能性明膠食品包裝膜及其制備方法.專利號(hào)：ZL201510137884.X
8.一種納米復(fù)合大豆蛋白塑料及其制備方法.專利號(hào)：ZL201510304629.X
9.一種納米銀復(fù)合膠原醫(yī)用敷料及其制備方法.專利號(hào)：ZL201710115523.4
10.一種孔道結(jié)構(gòu)可控的明膠細(xì)胞支架及其制備方法.專利號(hào)：ZL201810001229.5
11.一種腸道給藥載體巰基化海藻酸鈣微球及其制備方法.專利號(hào)：ZL201811592221.7
12.一種二硫鍵交聯(lián)的明膠/ε-聚賴氨酸活性食品包裝膜及其制備方法.專利號(hào): ZL201910312618.4
13.一種具有多重釋藥功能的載藥納米膠束及其制備方法.專利號(hào)：ZL202110277654.9
14.一種雙重載藥多糖基自愈合水凝膠及其制備方法.專利號(hào)：ZL202110912211.2
五、代表性學(xué)術(shù)論文：
55. Wang, Qi; Gan, Zhiyang; Wang, Xinxin; Li, Xinying; Zhao, Lei; Li, Derong; Xu, Zhilang; Mu, Changdao; Ge, Liming*;Defu Li*. Dissolving Hyaluronic Acid-Based Microneedles to Transdermally Deliver Eugenol Combined with Photothermal Therapy for Acne Vulgaris Treatment.ACS applied materials & interfaces, 2024, 16(17), 21595-21609
54. Weiwei Tan, Tao Long, Yanzhuo Wan, Bingchen Li, Zhilang Xu, Lei Zhao, Changdao Mu, Liming Ge,*,Defu Li,* Dual-drug loaded polysaccharide-based self-healing hydrogels with multifunctionality for promoting diabetic wound healing.Carbohydrate Polymers, 2023, 312, 120824
53. Tao Long, Weiwei Tan, Xiangmin Tian, Zongjian Tang, Keming Hu, Liming Ge, Changdao Mu, Xinying Li, Yongbin Xu, Lei Zhao,*Defu Li,*. Gelatin/alginate-based microspheres with sphere-in-capsule structure for spatiotemporal manipulative drug release in gastrointestinal tract,International Journal of Biological Macromolecules, 2023, 226, 485-495
52. Die Yang, Shilong Yang, Mingze Mu, Xueping Liu, Lei Zhao, Zhilang Xu, Changdao Mu,Defu Li,* and Liming Ge*. Multifunctional β-Cyclodextrin-Poly(ethylene glycol)-Cholesterol Nanomicelle for Anticancer Drug Delivery,ACS Applied Bio Materials, 2022, 5, 5418?5431
51. Lun Yuan, Ya Gao, Zhilang Xu, Guixin Chen, Liming Ge, Changdao Mu, Ye Tian,* andDefu Li*. Emulsion Template Fabrication of Antibacterial Gelatin-Based Scaffolds with a Preferred Microstructure for Accelerated Wound Healing.ACS Applied Polymer Materials, 2022, 4, 3885?3895
50.Liming Ge, Zijing Li, MiaoHan,Yongjie Wang, Xinying Li, Changdao Mu,Defu Li*. Antibacterial dialdehyde sodium alginate/ε-polylysine microspheres for fruit preservation,Food Chemistry, 2022, 387, 132885
49. Hongmei Zhou, Lun Yuan, Zhilang Xu, Xueling Yi, Xiao Wu, Changdao Mu, Liming Ge*,Defu Li*. Mimicking the Composition and Structure of Osteochondral to Fabricate Heterogeneous Three-Layer Scaffold for Repair of Osteochondral Defect,ACS Applied Bio Materials, 2022, 5, 2, 734-746
48.Yiruo He, Ye Tian, Wenjie Zhang, Xinghai Wang,Xue Yang, Bin Li, Liming Ge, Ding Bai*, andDefu Li*. Fabrication of oxidized sodium alginate-collagen heterogeneous bilayer barrier membrane with osteogenesis-promoting ability,International Journal of Biological Macromolecules, 2022, 202, 55-67
47.李德富，杜開峰.制藥分離工程課程教改初探.化工高等教育，2021，38（4），31-33
46. Shen Wang, Lun Yuan, Zhilang Xu, Xianyu Lin, Liming Ge,Defu Li,* Changdao Mu. Functionalization of Electroactive Self-healing Polypyrrole-Gelatin Based Hydrogel by Incorporating Polydopamine@AgNPs Nanocomposite.ACS Applied Bio Materials, 2021, 4, 5797?5808
45. Xia Wu, Xinying Li, Like Yang, Lun Yuan, Zhilang Xu, Jinfang Xu, Liming Ge, Changdao Mu,Defu Li*.Stability Enhanced Pickering Emulsions Based on Gelatin and Dialdehyde Starch Nanoparticles as Simple Strategy for Structuring Liquid Oils,Food and Bioprocess Technology, 2021, 14(8), 1600-1610
44.解曉芬，呂永博*，葛黎明，李德富*，穆暢道.氧化直鏈淀粉對(duì)姜黃素的增溶作用.生物加工過程, 2020, 18(3), 332-339.
43. Shen Wang, Jinfeng Lei, Xueling Yi, Lun Yuan, Liming Ge,Defu Li,* and Changdao Mu. Fabrication of Polypyrrole-Grafted Gelatin Based Hydrogel with Conductive, Self-Healing and Injectable Properties.ACS Applied Polymer Materials,2020, 2, 3016-3023
42.Lei Deng, Xinying Li,Keyan Miao, Xinyan Mao, Miao Han,Defu Li, Changdao Mu, Liming Ge*.Development ofdisulfidebondcrosslinkedgelatin/ε-polylysineactiveediblefilm withantibacterial andantioxidantactivities.Foodand Bioprocess Technology, 2020,13, 577–588
41.Xi Zhao,Xinying Li, Xiaofen Xie, Jinfeng Lei,Liming Ge,*Lun Yuan,Defu Li,*Changdao Mu.Controlling thePoreStructure ofCollagenSponge byAdjusting theCrosslinkingDegreefor Construction of HeterogeneousDouble-LayerBoneBarrierMembrane.ACS Applied Bio Materials,2020,2020, 3, 2058?2067
40. Yongbin Xu,Yaxin Zi,Jinfeng Lei, Xingyue Mo,Zilun Shao,Yuyao Wu, Ye Tian,*Defu Li,*Changdao Mu. pH-Responsivenanoparticlesbased on cholesterol/imidazole modifiedoxidized-starch fortargetedanticancerdrugdelivery.Carbohydrate Polymers, 2020,233,115858
39. Yongbo Lyu, Mengchao Yu, Qisong Liu, Qingmei Zhang, Zhanhong Liu, Ye Tian*,Defu Li*, Changdao Mu.Synthesis of silver nanoparticles using oxidized1amylose and combination with curcumin for enhanced antibacterial activity.Carbohydrate Polymers, 2020, 230,115573
38. Mingjin Zhu, Xinying Li,*, Liming Ge, Yaxin Zi, Man Qi, Yulin Li,Defu Li*, Changdao Mu. Green synthesis of κ-carrageenan@Ag submicron-particles with high aqueous stability, robust antibacterial activity and low cytotoxicity.Materials Science & Engineering C, 2020, 106, 110185-110194
37. Xinyan Mao, Xinying Li,Wenjie Zhang,Lun Yuan,Lei Deng,Liming Ge, Changdao Mu, andDefu Li*. Development of Microspheres Based on Thiol-Modified Sodium Alginate for Intestinal-Targeted Drug Delivery.ACS Applied Bio Materials, 2019, 2, 5810?5818
36. Jinfeng Lei, Xinying Li, Shen Wang, Lun Yuan, Liming Ge,Defu Li*, Changdao Mu.Facile Fabrication of Biocompatible Gelatin-Based Self-Healing Hydrogel.ACS Applied Polymer Materials, 2019, 1, 1350?1358
35.韓淼,李德榮,袁柳青,呂永博,葛黎明,李德富,穆暢道.雙醛淀粉還原制備納米銀及其在膠原基抗菌敷料中的應(yīng)用.高分子學(xué)報(bào), 2019, 50(4), 366-374
34. Lun Yuan, Xinying Li, Liming Ge, Xiaoqi Jia,Jinfeng Lei, Changdao Mu, andDefu Li*. Emulsion Template Method for the Fabrication of Gelatin-Based Scaffold with a Controllable Pore Structure.ACS Applied Materials & Interfaces, 2019, 11, 269?277.
33. Jinfeng Lei, Meizhou Zhang, Shen Wang, Lei Deng,Defu Li*, and Changdao Mu*.One-Pot Approach for the Synthesis of Water-Soluble Anatase TiO2Nanoparticle Cluster with Efficient Visible Light Photocatalytic Activity.The Journal of Physical Chemistry C,2018,122(46), 26447–26453.
32. Jinfeng Lei, Lei Deng, Xinying Li, Yongbin Xu,Defu Li*, Changdao Mu*. Comparative study of the physicochemical and photocatalytic properties of water-soluble polymer-capped TiO2nanoparticles.Environmental Science and Pollution Research, 2018, 25, 26259–26266.
31.梁偉杰，呂永博，穆暢道，李德富*.高性能正辛酸塑化明膠膜的熱壓法制備與表征.皮革科學(xué)與工程, 2018, 28(3), 11-19.
30. Liming Ge, Yongbin Xu, Xinying Li, Lun Yuan, Huan Tan,Defu Li*,Changdao Mu. Fabrication of Antibacterial Collagen-Based Composite Wound Dressing.ACS Sustainable Chemistry and Engineering. 2018,6(7), 9153–9166.
29. He Ren, Yongbo Lyu, Xinying Li, Shuxiao Zhang, Yusong Ye,Defu Li*, Changdao Mu*.Preparation and characterization of dialdehyde β-cyclodextrin with broad-spectrum antibacterial activity.Food Research International, 2018, 111, 237-243.
28. Liming Ge, Mingjin Zhu, Xinying Li, Yongbin Xu*, Xiaonan Ma, Rong Shi,Defu Li*, Changdao Mu. Development of active rosmarinic acid-gelatin biodegradable films with antioxidant and long-term antibacterial activities.Food Hydrocolloids, 2018, 83, 308-316.
27. Yaxin Zi, Mingjin Zhu, Xinying Li, Yongbin Xu, Hao Wei,Defu Li*,Changdao Mu*. Effects of carboxyl and aldehyde groups on the antibacterial activity of oxidized amylose.Carbohydrate Polymers192 (2018) 118-125.
26.訾婭鑫，雷金鳳，徐志朗，李德富*，穆暢道*.多糖的氧化改性及在生物醫(yī)藥領(lǐng)域的應(yīng)用.生物加工過程, 2018, 16(1): 31-37 (優(yōu)秀生物化工青年學(xué)者專刊)
25. Youxin Ye, He Ren, Shu Zhu, Huan Tan, Xinying Li*,Defu Li*, Changdao Mu. Synthesis of oxidized β-cyclodextrin with high aqueous solubility and broad-spectrum antimicrobial activity.Carbohydrate Polymers, 2017, 177: 97-104.
24. Yongbo Lyu, He Ren, Mengchao Yu, Xinying Li,Defu Li*, Changdao Mu*.Using oxidized amylose as carrier of linalool for the development of antibacterial wound dressing.Carbohydrate Polymers, 2017, 174, 1095–1105
23. Mingjin Zhu, Liming Ge, Yongbo Lyu, Yaxin Zi, Xinying Li*,Defu Li*, Changdao Mu.Preparation, characterization and antibacterial activity of oxidized κ-carrageenan.Carbohydrate Polymers, 2017, 174, 1051–1058.
22.Youxin Ye, Mingjin Zhu, Keyan Miao, Xinying Li*,Defu Li*, Changdao Mu.Development of antimicrobial gelatin-based edible films by incorporation of trans-anethole/β-cyclodextrin inclusion complex.Food and Bioprocess Technology, 2017, 10(10): 1844–1853.
21. Liming Ge, Mingjin Zhu, Yongbin Xu, Xinying Li*,Defu Li*, Changdao Mu.Development of antimicrobial and controlled biodegradable gelatin-based edible films containing nisin and amino-functionalized montmorillonite.Food and Bioprocess Technology, 2017, 10:1727–1736
20.Meizhou Zhang, Jinfeng Lei, Yifeng Shi, Lina Zhang, Youxin Ye,Defu Li*, Changdao Mu*. Molecular weight effects of PEG on the crystal structure and photocatalytic activities of PEG-capped TiO2nanoparticles.RSC Advances, 2016,6, 83366 - 83372
19. Ying Zhou, Youxin Ye, Wenwen Zhang, Songling Li, Jing Chen, Shiting Wang,Defu Li*, Changdao Mu*. Oxidized amylose with high carboxyl content: A promising solubilizer and carrier of linalool for antimicrobial activity.Carbohydrate Polymers,2016, 154, 13-19.
18. Liming Ge, Yongbin Xu, Weijie Liang, Xinying Li*,Defu Li*, Changdao Mu. Short-range and long-range cross-linking effects of polygenipin on gelatin-based composite materials.Journal of Biomedical Materials Research: Part A, 2016, 104A: 2712–2722.
17.Defu Li*, Youxin Ye, Derong Li, Xinying Li, Changdao Mu*. Biological properties of dialdehyde carboxymethyl cellulose crosslinked gelatin-PEG composite hydrogel fibers for wound dressings.Carbohydrate Polymers, 2016, 137, 508-514.
16. Ying Zhou, Xinying Li, Yongbo Lv, Yifeng Shi, Yu Zeng,Defu Li*, Changdao Mu*. Effect of oxidation level on the inclusion capacity and solution stability of oxidized amylose in aqueous solution.Carbohydrate Polymers,2016, 138, 41-48.
15. Liming Ge, Xinying Li, Run Zhang, Tianhan Yang, Xiaowei Ye,Defu Li*, Changdao Mu.Development and characterisation of dialdehyde xanthan gum crosslinked gelatin based edible films incorporated with amino-functionalized montmorillonite.Food Hydrocolloids, 2015, 51, 129-135.
14. Wenwen Zhang, Xinying Li, Taocheng Yu, Lun Yuan, Gang Rao,Defu Li*, Changdao Mu*. Physicochemical and release characterisation of the inclusion complex of β-cyclodextrin andtrans-anethole.Food Research International, 2015, 74, 55-62.
13. Kechen Li, Jiangen Peng, Meizhou Zhang, Jian Heng,Defu Li*, Changdao Mu*.Comparative study of the effects ofanatase and rutile titanium dioxide nanoparticlesonthe structure and properties of waterborne polyurethane.Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2015, 470, 92-99.
12. Jimin Guo, Liming Ge, Xinying Li, Changdao Mu,Defu Li*. Periodate oxidation of xanthan gum and its crosslinking effects on gelatin-based edible films.Food Hydrocolloids, 2014, 39, 243-250.
11. Xinying Li, Hongyan Ma, Huilian Huang,Defu Li, Shun Yao. Natural anthocyanins form phytoresources and their chemical researcher.Natural ProductResearch, 2013, 27(4-5): 456-469.
10. Changdao Mu, Ke Zhang, Wei Lin,Defu Li*.Ring-opening polymerization of genipin and its long-range crosslinking effect on collagen hydrogel.Journal of Biomedical Materials Research: Part A, 2013, 101A, 385-393.
9. Changdao Mu, Xinying Li, Yige Zhao, Hanguang Zhang, Liangjie Wang,Defu Li*.Freezing/thawing Effects on the Exfoliation of Montmorillonite in Gelatin-based Bionanocomposite.Journal of Applied Polymer Science, 2013, 128, 3141-3148.
8. Changdao Mu, Xinying Li, Jimin Guo, Caixia Bi,Defu Li*. Effects of Montmorillonite on the Structure and Properties of Gelatin-PEG Composite Fibers.Journal of Applied Polymer Science, 2013, 129, 773-778.
7. Jimin Guo, Xinying Li, Changdao Mu, Hanguang Zhang, Pan Qin,Defu Li*. Freezing-thawing effects on the properties of dialdehyde carboxymethyl cellulose crosslinked gelatin-MMT composite films.Food Hydrocolloids, 2013, 33, 273-279.
6. Changdao Mu, Jimin Guo, Xinying Li, Wei Lin,Defu Li*.Preparation and properties of dialdehyde carboxymethyl cellulose crosslinked gelatin edible films.Food Hydrocolloids, 2012, 27, 22-29. (ESI Top 1%高引用率論文)
5. Lirong He, Changdao Mu,Defu Li, Wei Lin.Revisit the pre-transition of type I collagen denaturation in dilute solution by ultrasensitive differential scanning calorimetry.Thermochimica Acta, 2012, 548, 1-5.
4. Dihan Su, Chunhua Wang, Sumei Cai, Changdao Mu,Defu Li, Wei Lin.Influence of palygorskite on the structure and thermal stability of collagen.Applied Clay Science, 2012, 62-63, 41-46.
3.Defu Li, Changdao Mu, Qian Zhang, Yuling Zhou, Wei Lin*. Effects of Microwave Irradiation on Collagen Denaturation.Journal of Food Biochemistry, 2010, 34, 1319-1331.
2.Defu Li, Changdao Mu, Cai Sumei, Wei Lin. Ultrasonicirradiation in the enzymatic extraction of collagen.Ultrasonics Sonochemistry, 2009, 16, 605-609.
1. Changdao Mu,Defu Li, Wei Lin, Yanwei Ding, and Guangzhao Zhang. Temperature induced denaturation of collagen in acidic solution.Biopolymers, 2007, 86(4), 282-287.
