教授/博士生導(dǎo)師
一.個(gè)人簡(jiǎn)介
四川大學(xué)beat365教授,博士生導(dǎo)師。四川省海外高層次留學(xué)人才,四川大學(xué)“化工之星”優(yōu)秀人才入選者,四川大學(xué)優(yōu)秀青年學(xué)者科研基金獲得者。2008年獲天津大學(xué)工學(xué)博士學(xué)位,同年入職四川大學(xué),曾赴美國(guó)加州大學(xué)洛杉磯分校和德國(guó)克勞斯塔爾工業(yè)大學(xué)交流訪問(wèn)。主要從事色譜分離及柱技術(shù)、生物質(zhì)資源化及診斷試劑開(kāi)發(fā)等研究,先后主持國(guó)家自然科學(xué)基金、企業(yè)等十多項(xiàng)科研項(xiàng)目,發(fā)表高水平SCI學(xué)術(shù)論文60多篇,發(fā)明專利11項(xiàng),出版專著和教材5部;科技部科技進(jìn)步獎(jiǎng)評(píng)委、教育部和國(guó)家自然基金委評(píng)審專家;《中國(guó)科技論文》編輯委員會(huì)委員(2019-2021);Biomed Research International(IF2.88)編輯。
實(shí)驗(yàn)室地址:四川大學(xué)江安校區(qū)第一基礎(chǔ)實(shí)驗(yàn)樓B415和B417室
實(shí)驗(yàn)室網(wǎng)址:https://www.x-mol.com/groups/Du_kaifeng
郵箱:kfdu@scu.edu.cn
二. 科研工作
主持科研項(xiàng)目10余項(xiàng),其中國(guó)家自然科學(xué)基金3項(xiàng),四川大學(xué)優(yōu)秀青年學(xué)者科研基金1項(xiàng),國(guó)家高技術(shù)項(xiàng)目及企業(yè)橫向項(xiàng)目3項(xiàng);在Chem. Eng. Sci., Ind. Eng. Chem. Res.,Chem. Eng. J.和J. Chromatogr. A等國(guó)際高水平SCI期刊上發(fā)表論文50多篇,它引總次數(shù)超過(guò)400多次,單篇最高它引次數(shù)超過(guò)90次,申報(bào)11項(xiàng)國(guó)家發(fā)明專利。擔(dān)任J. Chromatogr.A和 Chem. Eng. J.等多個(gè)國(guó)際期刊的特約審稿人。
2.1研究方向
1. 高效生物色譜介質(zhì)的設(shè)計(jì)合成與柱技術(shù)研究
新型生物色譜材料的研制;高通量、高選擇性吸附配基的設(shè)計(jì)合成及分離材料的表面修飾技術(shù);新型色譜介質(zhì)在生物和醫(yī)學(xué)工程應(yīng)用中的基本理論和技術(shù)研究。
2. 生物質(zhì)資源高效化研究
以木質(zhì)纖維素、瓊脂糖等天然高分子為研究對(duì)象,研究多糖基功能材料開(kāi)發(fā)及其高效化的基礎(chǔ)理論與應(yīng)用技術(shù),重點(diǎn)涉及材料結(jié)構(gòu)調(diào)控、表面修飾及其構(gòu)校關(guān)系研究。
3. 其他功能材料的開(kāi)發(fā)研究
生物活性磁性材料的合成及其在細(xì)胞篩選、核酸純化及免疫檢測(cè)中的應(yīng)用;核聚變靶丸的結(jié)構(gòu)設(shè)計(jì)與合成;二次鋰電池用高效電極材料的研制。
2.2科研項(xiàng)目(主持)
1.黃黃蜀葵花高效提制技術(shù)研究與產(chǎn)業(yè)化開(kāi)發(fā)(20H0750),川大-達(dá)州專項(xiàng)資金項(xiàng)目,2020-2022;40萬(wàn);
2.基于磁誘導(dǎo)聚合技術(shù)的有序多孔整體柱制備及其分離方法研究,國(guó)家自然科學(xué)基金(21676170), 2017-2020;
3.纖維素基多孔整體柱色譜介質(zhì)的合成與生物分離研究,國(guó)家自然科學(xué)基金項(xiàng)目(21476144),2015-2018;
4.具有陣列多孔結(jié)構(gòu)的整體柱制備及分離方法研究,四川大學(xué)優(yōu)秀青年學(xué)者科研基金(2014SCU04A04),2014-2016;
5.有序多孔有機(jī)整體柱的制備及其生物色譜研究,國(guó)家自然科學(xué)基金(21206097),2013-2015;
6.雙孔纖維素微球的制備及放大工藝研究,企業(yè)委托項(xiàng)目(12H0487),2012-2015;
7.多層球結(jié)構(gòu)設(shè)計(jì)與制備方法研究,橫向項(xiàng)目(HG2011046 ),2012-2014;
2.3近年發(fā)表的代表性論文(均為第一或通訊作者)
1. Tian Yao, Yuxin Liao, Shasha Li, Liangzhi Qiao,Kaifeng Du*, Bisphosphonated-immobilized porous cellulose monolith with tentacle grafting by atom transfer radical polymerization for selective adsorption of lysozyme,Journal of Chromatography A,Volume 1651,2021,462337.
2. Tian Yao, Qiang Li, Hongmei Li, Lianxin Peng, Yang Liu,Kaifeng Du*,Extractive resolution of racemic phenylalanine and preparation of optically pure product by chiral magnetic ionic liquid aqueous two-phase system,Separation and Purification Technology,Volume 274, 2021,119024.
3. Qiao, L., Liang, C. &Du, Kaifeng*. Homogeneous and stable carbon nanotube dispersion assisted by cellulose in NaOH/thiourea aqueous solution. Cellulose ,2021,28,5421-5431;.
4. Liangshen Zhao, Shasha Li, Chao Liang, Liangzhi Qiao,Kaifeng Du*, High-strength and low-crystallinity cellulose/agarose composite microspheres: Fabrication, characterization and protein adsorption, Biochemical Engineering Journal, Volume 166, 2021,107826
5. Liangzhi Qiao, Susu Lei,Kaifeng Du*, High-surface-area interconnected macroporous nanofibrous cellulose microspheres: a versatile platform for large capacity and high-throughput protein separation. Cellulose, 2021,28, 1-12.
6. Liangshen Zhao, Shasha Li, Wenhui Wang, Yinghong Wang,Kaifeng Du*, Preparation and characterization of highly porous cellulose-agarose composite chromatographic microspheres for enhanced selective separation of histidine-rich proteins, Journal of Chromatography A, Volume 1637,2021,461831.
7. Yi Liu, Liangzhi Qiao, Anjing Wang, Yaling Li, Liangshen Zhao,Kaifeng Du*,Tentacle-type poly(hydroxamic acid)-modified macroporous cellulose beads: Synthesis, characterization, and application for heavy metal ions adsorption, Journal of Chromatography A,Volume 1645,2021, 462098.
8. Liangshen Zhao, Chao Liang, Shasha Li,Kaifeng Du*, Study of tentacle-like cationic macroporous cellulose spherical adsorbent for heavy metals, Journal of Cleaner Production, Volume 303, 2021,127114.
9.喬亮智,杜開(kāi)峰.天然多糖微球的制備及功能應(yīng)用[J/OL].化工進(jìn)展:1-10[2021-07-03].1000-6613.2020-2012.
10. Tian Yao,Kaifeng Du*, Simultaneous determination of sulfonamides in milk: In-situ magnetic ionic liquid dispersive liquid-liquid microextraction coupled with HPLC, Food Chemistry, Volume 331,2020, 127342
11. Hao Ai, Liangzhi Qiao, Liangshen Zhao, Shasha Li, andKaifeng Du*,Fabrication and Characterization of Anisotropic Porous Poly(styrene@acrylic acid) Monolith for Enhanced Ability of Heavy Metal Adsorption,Ind. Eng. Chem. Res. 2020, 59, 7816?7824;
12. Tian Yao andKaifeng Du*,Measurement and Correlation of Solubility of Benzothiazolium Ionic Liquids in Ethanol + Ethyl Benzoate,J. Chem. Eng. Data 2020, 65, 777?787;
13. Liangzhi Qiao, Liangshen Zhao,Kaifeng Du?,Construction of hierarchically porous chitin microspheres via a novel Dual-template strategy for rapid and High-capacity removal of heavy metal ions,Chemical Engineering Journal 393 (2020) 124818;
14. Liangzhi Qiao, Shasha Li, Yaling Li, Yi Liu,Kaifeng Du*,Fabrication of superporous cellulose beads via enhanced inner cross-linked linkages for high ef?cient adsorption of heavy metal ions,Journal of Cleaner Production 253 (2020) 120017
15.Kaifeng Du, Tian Yao*, The C–H activated controlled mono- and di-ole?nation of arenes in ionic liquids at room temperature, RSC Advances,2020, 10,3203-3211;
16. Liangzhi Qiao, Shasha Li,Kaifeng Du*Fabrication and characterization of porous cellulose beads with high strength and specific surface area via preliminary chemical cross-linking reaction for protein separation Biochemical Engineering Journal 153 (2020) 107412 IF3.371
17. Tian Yao, Hao Ai, andKaifeng Du*, High tough and highly porous graphene/carbon nanotubes hybrid beads enhanced by carbonized polyacrylonitrile for efficient dyes adsorption, Microporous and Mesoporous Materials 292 (2020) 109716 IF4.182
18. Chao Liang, Liangshen Zhao, Shasha Li, Liangzhi Qiao, Tao Wang,Kaifeng Du*, Direct preparation of porous cellulose microspheres via a self-growth process on bamboo fibers and their functionalization for specific adsorption of histidine-rich proteins, Journal of Chromatography A, Volume 1633, 2020, 461636,ISSN 0021-9673.
19. Liangzhi Qiao, Yaling Li, Yi Liu, Yinghong Wang,Kaifeng Du, High-strength, blood-compatible, and high-capacity bilirubin adsorbent based on cellulose-assisted high-quality dispersion of carbon nanotubes, Journal of Chromatography A, Volume 1634, 2020, 461659,ISSN 0021-9673.
20.艾浩,王文慧,杜開(kāi)峰.石墨烯/殼聚糖復(fù)合微球的制備及其蛋白質(zhì)吸附評(píng)價(jià)[J].中國(guó)科技論文,2020,15(12):1352-1358+1370.
21.杜開(kāi)峰*,喬亮智,纖維素基功能材料,工程科學(xué)與技術(shù),綜述,2019,51(3),9-16.
22. Liangzhi Qiao,Kaifeng Du*, Construction of porous chitosan microspheres with high special surface area by using agarose as pore-form agent and further functionalized application in bioseparation,Journal of Materials Chemistry B, 2019,7,5510-5519
23. Liangzhi Qiao, Liangshen Zhao, Hao Ai, Yaling Li, Yi Liu, andKaifeng Du*,Diethylaminoethyl-Modified Magnetic Starlike Organic Spherical Adsorbent: Fabrication, Characterization, and Potential for Protein Adsorption,Ind. Eng. Chem. Res., 2019, 58 (10), pp 4099–4107
24. Tian Yao, andKaifeng Du*,Temperature-Controlled Mono- and Diolefination of Arene Using Rh(III)/RTIL as an Efficient and Recyclable Catalytic System,ACS Sustainable Chem. Eng.,2019,7(6), pp 6068–6077
25.Kaifeng Du,*Shikai Li, Liangshen Zhao, Liangzhi Qiao, Hao Ai, and Xiaohong Liu, One-Step Growth of Porous Cellulose Beads Directly on Bamboo Fibers via Oxidation-Derived Method in Aqueous Phase and Their Potential for Heavy Metal Ions Adsorption, ACS Sustainable Chem. Eng.,2018,6(12), pp 17068–17075
26.Kaifeng Du,*Xiaohong Liu, Shikai Li, Liangzhi Qiao, and Hao Ai, Synthesis of Cu2+ Chelated Cellulose/Magnetic Hydroxyapatite Particles Hybrid Beads and Their Potential for High Speci?c Adsorption of Histidine-Rich Proteins, ACS Sustainable Chem. Eng.,2018,2018,6(9), pp 11578–11586
27.Kaifeng Du*, Shunmin Dan, Reversible Concanavalin A (Con A) ligands immobilization on metal chelated macroporous cellulose monolith and its selective adsorption for glycoproteins, Journal of Chromatography A, 2018, 1548, 37–43
28. Qi Zhang, Shunmin Dan, andKaifeng Du*?Fabrication and Characterization of Magnetic Hydroxyapatite Entrapped Agarose Composite Beads with High Adsorption Capacity for Heavy Metal Removal,Industrial & Engineering Chemistry Research,2017, 56, 8705–8712.
29.Kaifeng Du*, Ionic liquid-regenerated macroporous cellulose monolith: Fabrication, characterization and its protein chromatography, Journal of Chromatography A, 2017, 1494, 40–45
30.Kaifeng Du*, Qi Zhang, Facile fabrication of sulfur entrapped carbonized material as a cathode for high-performance lithium batteries, RSC advances, 2016, 6, 87690-87695.
31.Kaifeng Du*, Qi Zhang, Shunmin Dan, Min Yang, Yonkui, Zhang, Fabrication and characterization of aligned macroporous monolith for high-performance protein chromatography,Journal of Chromatography A, 2016, 1443,111-117;
32.Kaifeng Du*, Min Yang, Qi Zhang, Shunmin Dan?, Highly Porous Polymer Monolith Immobilized with Aptamer (RNA) Anchored Grafted Tentacles and Its Potential for the Purification of Lysozyme,Industrial & Engineering Chemistry Research,2016,52, 499-504;
2.4發(fā)明專利(均為第一發(fā)明人)
[1]杜開(kāi)峰、但順民,一種具有可逆修飾的凝聚素基親和色譜柱的制備方法,專利號(hào)CN201710938099.3(2020年授權(quán));
[2]杜開(kāi)峰、張琦、楊敏,一種復(fù)合磁性羥基磷灰石大球吸附材料的制備方法,專利號(hào)CN201710130967.5(2019年授權(quán))。
[3]杜開(kāi)峰、但順民,一種星形磁響應(yīng)有機(jī)吸附材料及其制備方法,專利號(hào)201710300145.7(2019年授權(quán));
[4]杜開(kāi)峰、崔旭東、李響、張永奎,一種鋰二次電池用硫化聚丙烯腈正極材料的制備方法,專利號(hào)ZL201410194569.6 (2017年授權(quán));
[5]杜開(kāi)峰,李響,一種大孔纖維素色譜微球的綠色合成新方法,專利號(hào)201510120168.0
[6]杜開(kāi)峰,楊敏,一種高度多孔的二氧化鈦膜光催化劑的制備方法,專利號(hào)201610069356.x
[7]杜開(kāi)峰,張琦,一種有序大孔整體柱色譜材料的制備方法,專利號(hào)201510973319.7
[8]杜開(kāi)峰,楊敏,一種大孔纖維素色譜微球的綠色合成新方法,專利號(hào)201510120168.0。
三.教育教學(xué)
3.1課程教學(xué)
生物基化學(xué)品技術(shù);技術(shù)經(jīng)濟(jì)和項(xiàng)目管理;制藥分離工程;生物分離工程,化工技術(shù)經(jīng)濟(jì)(研究生課程)。
3.2課程和教材建設(shè)
負(fù)責(zé)的《制藥分離工程》課程被認(rèn)定第二批省級(jí)線上線下混合式一流課程(2021年);化工技術(shù)經(jīng)濟(jì)第三版(副主編,國(guó)家級(jí)規(guī)劃教材,化學(xué)工業(yè)出版社,2012);生物信息學(xué)導(dǎo)論(主編,水利水電出版社,2015);化工技術(shù)經(jīng)濟(jì)第四版(副主編,化學(xué)工業(yè)出版社,2018),制藥分離工程(副主編,2019年,科學(xué)出版社);醫(yī)藥技術(shù)經(jīng)濟(jì)(副主編,2019年,科學(xué)出版社)。
3.3教改項(xiàng)目(主持)
主持并完成4項(xiàng)省級(jí)、校級(jí)教學(xué)改革項(xiàng)目
1.生物與制藥工程專業(yè)一體化創(chuàng)新人才培養(yǎng)模式的探索,四川省項(xiàng)目,2011-2014;
2.生物工程類拔尖創(chuàng)新人才綜合培養(yǎng)體系的研究與實(shí)踐(過(guò)程裝備與控制工程專業(yè)綜合改革),四川省項(xiàng)目,2011-2013;
3.《生物能源》課程探究式課堂教學(xué)方式改革與實(shí)踐,川大教(2011)97號(hào),2011-2013;
4.四川大學(xué)學(xué)術(shù)學(xué)位研究生教材建設(shè)項(xiàng)目《工業(yè)技術(shù)經(jīng)濟(jì)和項(xiàng)目管理》研究生教材,項(xiàng)目編號(hào)1030704117006,2017-2019。
四、獎(jiǎng)勵(lì)及其他
1. “四川省海外高層次留學(xué)人才”榮譽(yù)稱號(hào),2014
2.“化工之星”優(yōu)秀人才獎(jiǎng)獲得2016
3.四川大學(xué)優(yōu)秀青年學(xué)者科研基金獲得者2014
4.四川大學(xué)優(yōu)秀共產(chǎn)黨員,2014
5.四川大學(xué)優(yōu)秀教師,2014
6.四川大學(xué)青年骨干教師獎(jiǎng),2014
7.四川大學(xué)青年骨干教師獎(jiǎng), 2011
8.四川大學(xué)青年骨干教師獎(jiǎng),2010
9.全國(guó)制藥工程研究壁報(bào)大賽(指導(dǎo)教師)三等獎(jiǎng),2011
10.全國(guó)制藥工程研究論文大賽(本科組)(指導(dǎo)教師)一等獎(jiǎng),2015
11.四川大學(xué)本科優(yōu)秀畢業(yè)論文指導(dǎo)教師)二等獎(jiǎng),2016
12.四川大學(xué)學(xué)術(shù)型社團(tuán)指導(dǎo)教師優(yōu)秀獎(jiǎng),2016
13. Certificate of Outstanding Contribution in Reviewing by Journal of Chromatography A 2017
五、本科生科研成果
指導(dǎo)的多組本科生獲得國(guó)家級(jí)和省級(jí)大學(xué)生創(chuàng)新創(chuàng)業(yè)項(xiàng)目支持,多名本科生在全國(guó)大賽和學(xué)術(shù)會(huì)議上獲得獎(jiǎng)項(xiàng)。
1.邱浩然,磁響應(yīng)星形有機(jī)吸附劑材料的制備及性能表征,201710611242,國(guó)家級(jí)項(xiàng)目;
2.唐彬,多層次中空無(wú)機(jī)微球的結(jié)構(gòu)設(shè)計(jì)與制備新方法研究,201210610039,國(guó)家級(jí)項(xiàng)目;
3.??【埃滦投嗫资杷吞疾牧系闹苽浼靶阅鼙碚?,201610610650省級(jí)項(xiàng)目;
4.柴德治,有序多孔有機(jī)整體柱的制備及其生物色譜研究,項(xiàng)目編號(hào)201510610523,省級(jí)項(xiàng)目,大學(xué)生創(chuàng)新創(chuàng)業(yè)訓(xùn)練計(jì)劃;
5.劉倩獲得2015年全國(guó)學(xué)生制藥工程研究征文大賽(本科組)一等獎(jiǎng);
6.本科生張琦在2015年的化工年會(huì)上獲得優(yōu)秀論文獎(jiǎng)。