1.個(gè)人簡(jiǎn)介
副研究員/碩士生導(dǎo)師
電話：18200261093
郵箱：qiaomeisun@163.com
2015年獲四川大學(xué)制藥工程學(xué)士學(xué)位
2020年獲四川大學(xué)制藥工程博士學(xué)位
2020年7月任職于beat365，任制藥工程專業(yè)教研室主任
實(shí)驗(yàn)室地址：四川大學(xué)望江校區(qū)beat365310、316和318室
2.科研工作
研究方向主要聚焦于醫(yī)藥健康和生命科學(xué)領(lǐng)域，開(kāi)展多學(xué)科交叉融合研究，研究課題主要包括蛋白-藥物超分子體系、藥物遞送體系、計(jì)算機(jī)輔助藥物設(shè)計(jì)和藥物晶體學(xué)方向的基礎(chǔ)研究及工程應(yīng)用轉(zhuǎn)化。目前已發(fā)表SCI論文40余篇，ESI高被引論文1篇。承擔(dān)國(guó)家自然科學(xué)基金、國(guó)家博士后基金等科研項(xiàng)目10余項(xiàng)。
2.1研究方向
（1） 蛋白-配體超分子體系相互作用研究
建立蛋白質(zhì)、多肽、DNA等生物大分子與藥物、天然活性成分等化學(xué)小分子之間的相互識(shí)別模式，是化學(xué)、藥學(xué)以及生命科學(xué)等多學(xué)科領(lǐng)域的研究熱點(diǎn)?；诙喾N現(xiàn)代分析測(cè)試技術(shù)和計(jì)算機(jī)模擬等手段，對(duì)作用機(jī)理、結(jié)合方式、結(jié)構(gòu)特性、結(jié)合構(gòu)象進(jìn)行深入探討，有助于了解蛋白質(zhì)結(jié)構(gòu)和功能等生物學(xué)本質(zhì)，為理解藥代動(dòng)力學(xué)和藥效學(xué)提供理論依據(jù)。
（2） 藥物靶向遞送體系研究
提高藥物的靶向性和治療效果，實(shí)現(xiàn)藥物智能遞送和控制釋放是藥劑學(xué)的重要研究課題之一，基于環(huán)糊精、MOF、脂質(zhì)體等生物功能材料，利用納米技術(shù)、分子生物學(xué)和藥物化學(xué)方法，開(kāi)發(fā)新型藥物載體和遞送系統(tǒng)，實(shí)現(xiàn)藥物的靶向遞送和控釋。
（3） 藥物晶體學(xué)研究
晶型、單晶、共晶、多晶研究是藥物一致性評(píng)價(jià)和新藥研發(fā)的重要環(huán)節(jié)，不同的藥物固體形態(tài)具有不同的熔點(diǎn)、溶出、穩(wěn)定性等理化性質(zhì)，從而影響藥物的藥效、毒副作用和生物利用度。通過(guò)對(duì)結(jié)晶和轉(zhuǎn)晶過(guò)程研究，篩選優(yōu)勢(shì)晶型，明確晶體結(jié)構(gòu)，為后續(xù)優(yōu)勢(shì)固態(tài)藥用形式設(shè)計(jì)提供基礎(chǔ)。
2.2主持科研項(xiàng)目
l環(huán)糊精介導(dǎo)偶氮類化合物光控開(kāi)關(guān)調(diào)控α-乳白蛋白的折疊過(guò)程研究，國(guó)家自然科學(xué)基金青年基金，30萬(wàn)元，2022-2024
lCD-MOF開(kāi)關(guān)光誘導(dǎo)胸腺肽α1構(gòu)象可逆調(diào)控的機(jī)理研究，中國(guó)博士后科學(xué)基金第71批面上項(xiàng)目，8萬(wàn)元，2022-2024
l基于智能分子軌跡分析技術(shù)的藥物-藥物作用機(jī)理研究，四川大學(xué)交叉學(xué)科基金，10萬(wàn)元，2022-2023
l光響應(yīng)MOF開(kāi)關(guān)誘導(dǎo)胸腺肽1構(gòu)象折疊的機(jī)理研究，四川大學(xué)博士后基金，15萬(wàn)元，2022-2024
l尼古丁與有機(jī)酸氣相反應(yīng)產(chǎn)物在體內(nèi)轉(zhuǎn)運(yùn)及作用機(jī)理研究，橫向項(xiàng)目，48萬(wàn)元，2019-2022
l血培養(yǎng)試劑組分含量研究，橫向項(xiàng)目，8萬(wàn)元，2021
l孟魯司特鈉的體內(nèi)作用機(jī)理研究，橫向項(xiàng)目，3萬(wàn)元，2021-2022
l新型煙草產(chǎn)品中煙堿鹽制備與表征及其釋放機(jī)理研究服務(wù)合同，橫向項(xiàng)目，78萬(wàn)，2021-2023
l色譜柱填充材料鍵合工藝開(kāi)發(fā)技術(shù)服務(wù)合同，橫向項(xiàng)目，7萬(wàn)元，2022
l加熱卷煙專用料香及其遞送調(diào)控技術(shù)開(kāi)發(fā)，橫向項(xiàng)目，48.05萬(wàn)元，2023
2.3近年發(fā)表的代表性論文
[1] Haobin Xia,Qiaomei Sun *, Na Gan, Pu Ai, Hui Li and Yanfang Li*. Unveiling the binding details and esterase-like activity effect of methyl yellow on human serum albumin: spectroscopic and simulation study.RSC Advances,2023,13:8281
[2] Zhiqiang Li, Ludan Zhao,Qiaomei Sun*, Na Gan, Qiyi Zhang*, Ji Yang, Bin Yi, Xiaoxiang Liao,Donglai Zhu, Hui Li. Study on the interaction between 2,6-dihydroxybenzoic acid nicotine salt and human serum albumin by multi-spectroscopy and molecular dynamics simulation.Spectrochimica Acta Part A:,2022,270:120868.
[3] Xi Xiang,Qiaomei Sun*, Na Gan, Zili Suo, Shuangshuang Zhang, Shun Yao*, Hongzhao Xiang,Na Yuan, Hui Li. Interaction between berberine hydrochloride and β-lactoglobulin of two structures by heat treatment.Food Hydrocolloids, 2022, 123:107168
[4] Na Gan, Xu Peng, Di Wu, Hongzhao Xiang,Qiaomei Sun*, Bin Yi, Zili Suo, Shuangshuang Zhang, Xinlong Wang*, Hui Li.Effects of microsize on the biocompatibility of UiO67 from protein-adsorption behavior, hemocompatibility, and histological toxicity.Journal of Hazardous Materials, 2022, 435:129042
[5]Qiaomei Sun,Yuanming Zhai*, Wenjing Wang, Na Gan, Shuangshuang Zhang, Zili Suo, Hui Li*,Molecular recognition patterns between vitamin B12 and human serum albumin explored through STD–NMR and spectroscopic methods.Spectrochimica Acta Part A,258 (2021) 119828.
[6] Na Gan,Qiaomei Sun*, Ludan Zhao, Shuangshuang Zhang, Zili Suo,Xinlong Wang*, Hui Li. Hierarchical core–shell nanoplatforms constructed from Fe3O4@C and metal–organic frameworks with excellent bilirubin removal performance.Journal of Materials Chemistry B, 2021, 9: 5628（封面文章）
[7] Shuangshuang Zhang,Qiaomei Sun*, Xu Peng, Na Gan,Ludan Zhao,Zili Suo, Gang Zhao*, Hui Li.A pH-sensitive T7 peptide-decorated liposome system for HER2 inhibitor extracellular delivery: an application for the efficient suppression of HER2+ breast cancer.Journal of Materials Chemistry B, 2021, 9:8768.（封面文章）
[8] Hongzhao Xiang,Qiaomei Sun*, Wenjing Wang, Sai Li a*, Xi Xiang, Zhiqiang Li,Xiaoxiang Liao, Hui Li.Study of conformational and functional changes caused by binding of environmental pollutant tonalide to human serum albumin.Chemosphere, 2021,270:129431.
[9] Shuangshuang Zhang, Ludan Zhao, Xu Peng,Qiaomei Sun *, Xiaoxiang Liao, Na Gan, Gang Zhao a*, Hui Li. Self-assembled phospholipid-based mixed micelles for improving the solubility, bioavailability and anticancer activity of lenvatinib.Colloids and Surfaces B: Biointerfaces, 2021, 201:111644.
[10] Shuangshuang Zhang, Ruixue Gan, Ludan Zhao,Qiaomei Sun*, Hongzhao Xiang, Xi Xiang, Gang Zhao*, Hui Li. Unveiling the interaction mechanism of alogliptin benzoate with human serum albumin: Insights from spectroscopy, microcalorimetry, and molecular docking and molecular dynamics analyses.Spectrochimica Acta Part A, 2021,246:119040.
[11] Na Gan,Qiaomei Sun?, Zili Suo, Shuangshuang Zhang, Ludan Zhao,Hongzhao Xiang, Wenjing Wang, Zhiqiang Li, Xiaoxiang Liao, Hui Li?.How hydrophilic group affects drug–protein binding modes:Differences in interaction between sirtuins inhibitors Tenovin-1/Tenovin-6 and human serum albumin.Journal of Pharmaceutical and Biomedical Analysis, 2021, 201: 114121.
[12] Zili Suo,Qiaomei Sun?, Xin Wei, Na Yuan, Na Gan, Peng Wang, Yongkui Zhanga?, Hui Li.A New Reasonable Interpretation of Azilsartan Form II: aHydrate.Journal of Molecular Structure, 2021, 1243: 130867.
[13]Wenjing Wang,Qiaomei Sun*, Na Gan, Yuanming Zhai*, Hongzhao Xiang,Hui Li. Characterizing the interaction between methyl ferulate and human serum albumin by saturation transfer difference NMR, RSC Advances, 2020,10,32999.
[14]Sun Qiaomei, He Jiawei, Yang Hongqin, Li Shanshan, Zhao Ludan, Li Hui. Analysis of binding properties and interaction of thiabendazole and its metabolite with human serum albumin via multiple spectroscopic methods[J].Food Chemistry, 2017, 233: 190-196.
[15]Sun Qiaomei, Yang Hongqin, Tang Peixiao, Liu Jiuyang, Wang Wan, Li Hui. Interactions of cinnamaldehyde and its metabolite cinnamic acid with human serum albumin and interference of other food additives[J].Food Chemistry, 2018, 243: 74-81.(ESI高被引論文)
[16]Sun Qiaomei, Tang Peixiao, Zhao Ludan, Pu Hongyu, Zhai Yuanming, Li Hui. Mechanism and structure studies of cinnamaldehyde/cyclodextrins inclusions by computer simulation and NMR technology[J].Carbohydrate Polymers, 2018, 194: 294-302.
[17]Sun Qiaomei, Suo Zili, Pu Hongyu, Tang Peixiao, Gan Na, Gan Ruixue, Zhai Yuanming, Ding Xiaohui, Li Hui. Studies of the binding properties of the food preservative thiabendazole to DNA by computer simulations and NMR relaxation[J].Rsc Advances, 2018, 8(36): 20295-20303.
[18]Sun Qiaomei, Gan Na, Zhang Shuangshuang, Zhao Ludan, Tang Peixiao, Pu Hongyu, Zhai Yuanming, Gan Ruixue, Li Hui. Insights into protein recognition for gamma-lactone essences and the effect of side chains on interaction via microscopic, spectroscopic, and simulative technologies[J].Food Chemistry, 2019, 278: 127-135.
3．教育教學(xué)
3.1課程教學(xué)
EHS導(dǎo)論；工業(yè)藥劑學(xué)；藥物分析及制藥過(guò)程檢測(cè)
3.2本科生科研成果
（1）四川大學(xué)本科優(yōu)秀畢業(yè)論文指導(dǎo)教師三等獎(jiǎng)，2021
（2）蔡涌臣，微米級(jí)γ-環(huán)糊精金屬有機(jī)框架的制備和包封姜黃素，2024
（3）丁鈴雙，熱處理對(duì)乳清蛋白結(jié)構(gòu)和功能穩(wěn)定性的研究，2023
（4）王楠，環(huán)糊精包合改善卡培他濱溶解度的結(jié)構(gòu)特性和理論研究，2023,
（5）朱璐楊，光響應(yīng)MOF材料的制備表征及光響應(yīng)特性研究，2023
（6）劉玉池，基于金屬-有機(jī)骨架的磁性核殼結(jié)構(gòu)納米平臺(tái)的構(gòu)建及其在血液灌流中的應(yīng)用研究，2022
（7）方心怡，白三烯受體拮抗劑孟魯司特鈉的血漿蛋白結(jié)合特性研究，2022
（8）方心怡，白三烯受體拮抗劑孟魯司特鈉的血漿蛋白結(jié)合特性研究，2021
