葛黎明 副教授/碩士研究生生導(dǎo)師
研究方向：生物質(zhì)化學(xué)與材料
辦公地點(diǎn)：四川大學(xué)望江校區(qū)beat365228室
聯(lián)系方式：geliming@scu.edu.cn
個(gè)人簡(jiǎn)介：
2019年6月畢業(yè)于四川大學(xué)，獲工學(xué)博士學(xué)位。研究方向?yàn)樯镔|(zhì)化學(xué)與材料，長(zhǎng)期從事膠原和多糖基功能性復(fù)合材料在食品和生物醫(yī)藥領(lǐng)域的應(yīng)用基礎(chǔ)研究工作。主持國(guó)家自然科學(xué)基金青年科學(xué)基金項(xiàng)目、四川省應(yīng)用基礎(chǔ)研究項(xiàng)目、四川大學(xué)博士后交叉學(xué)科創(chuàng)新啟動(dòng)基金項(xiàng)目、皮革化學(xué)與工程教育部重點(diǎn)實(shí)驗(yàn)室開(kāi)放課題和企業(yè)委托項(xiàng)目等。以第一作者或通訊作者在Advanced Healthcare Materials，ACS Applied Materials & Interfaces，ACS Sustainable Chemistry & Engineering，Biomaterials Advances，Carbohydrate Polymers等學(xué)術(shù)期刊上發(fā)表了20余篇研究論文，以第一發(fā)明人獲授權(quán)發(fā)明專利4件。指導(dǎo)本科生獲得第十二屆全國(guó)大學(xué)生藥苑論壇“創(chuàng)新成果一等獎(jiǎng)”和“優(yōu)秀論文獎(jiǎng)”，榮獲四川大學(xué)大學(xué)生創(chuàng)新創(chuàng)業(yè)與實(shí)踐教育優(yōu)秀指導(dǎo)教師等榮譽(yù)。
教育經(jīng)歷：
2014.9-2019.6，四川大學(xué)，生物化工專業(yè)，工學(xué)博士（碩博連讀），導(dǎo)師：穆暢道教授
2010.9-2014.6，四川大學(xué)，生物工程專業(yè)，工學(xué)學(xué)士
工作經(jīng)歷：
2023.9-今，四川大學(xué)，beat365制藥與生物工程系，副教授
2022.7-今，四川大學(xué)，beat365制藥與生物工程系，碩士研究生導(dǎo)師
2022.5-2023.8，四川大學(xué)，beat365制藥與生物工程系，副研究員（專職科研）
2019.7-2022.4，四川大學(xué)，beat365制藥與生物工程系，助理研究員
2019.7-2022.11，四川大學(xué)，化學(xué)工程與技術(shù)，專職博士后
教學(xué)工作：
主要講授制藥工程專業(yè)本科和研究生的課程：《制藥工程設(shè)計(jì)》、《藥品生產(chǎn)質(zhì)量工程》、《制藥工程專業(yè)文獻(xiàn)檢索與研讀》、《制藥生產(chǎn)實(shí)習(xí)》、《微生物學(xué)實(shí)驗(yàn)II》等。
科研項(xiàng)目：
1.國(guó)家自然科學(xué)基金青年科學(xué)基金項(xiàng)目，項(xiàng)目號(hào): 22305164，2024.1~2026.12，項(xiàng)目負(fù)責(zé)人。
2.四川省應(yīng)用基礎(chǔ)研究項(xiàng)目，項(xiàng)目號(hào): 2021YJ0478，2021.4~2023.3，項(xiàng)目負(fù)責(zé)人。
3.四川大學(xué)博士后交叉學(xué)科創(chuàng)新啟動(dòng)基金項(xiàng)目，2021.1~2022.12，項(xiàng)目負(fù)責(zé)人。
4.四川大學(xué)專職博士后研發(fā)基金，項(xiàng)目號(hào): 2021SCU12085，2021.1~2022.12，項(xiàng)目負(fù)責(zé)人。
5.皮革化學(xué)與工程教育部重點(diǎn)實(shí)驗(yàn)室開(kāi)放課題，2022.1.1~2022.12.31，項(xiàng)目負(fù)責(zé)人。
6.企業(yè)委托項(xiàng)目，合同號(hào): 21H0387，2021.6~2023.5，項(xiàng)目負(fù)責(zé)人。
7.企業(yè)委托項(xiàng)目，合同號(hào): 21H0986，2021.9.15~2022.2.28，項(xiàng)目負(fù)責(zé)人。
8.企業(yè)委托項(xiàng)目，合同號(hào): 21H1052，2021.10.20~2021.12.20，項(xiàng)目負(fù)責(zé)人。
9.企業(yè)委托項(xiàng)目，合同號(hào): 22H0955，2022.8.17-2022.11.30，項(xiàng)目負(fù)責(zé)人。
研究論文：
28. Weidong Liao, Die Yang, Zhilang Xu, Lei Zhao, Changdao Mu, Defu Li,Liming Ge*. Antibacterial collagen-based nanocomposite dressings for promoting infected wound healing[J].Advanced Healthcare Materials, 2023, 12(15): 2203054.
27. Xianyu Lin, Xue Yang, Panyu Li, Zhilang Xu, Lei Zhao, Changdao Mu, Defu Li,Liming Ge*. Antibacterial conductive collagen-based hydrogels for accelerated full-thickness wound healing[J].ACS Applied Materials & Interfaces, 2023, 15(19): 22817-22829.
26. Weiwei Tan, Tao Long, Yanzhuo Wan, Bingchen Li, Zhilang Xu, Lei Zhao, Changdao Mu,Liming Ge*, Defu Li*. Dual-drug loaded polysaccharide-based self-healing hydrogels with multifunctionality for promoting diabetic wound healing[J].Carbohydrate Polymers, 2023, 312: 120824.
25.王欣欣,吳霞,李德富,穆暢道,葛黎明*.明膠納米顆粒穩(wěn)定的Pickering乳液的制備及表征[J].食品與發(fā)酵工業(yè), 2023, 49(1): 124-131.
24.譚魏葳,雷蘇蘇,龍濤,徐志朗,李德富,穆暢道,葛黎明*.具有葡萄糖響應(yīng)性釋藥的多糖基可注射自愈合水凝膠[J].高分子學(xué)報(bào), 2023, 54(8): 1155-1165.
22. Xiaxi Pan, Guixin Chen, Ting Xu, Lingyue Kong, Xinying Li, Defu Li, Changdao Mu, Zhilang Xu*, Liming Ge*. Gelatin-based active edible film with pH-sensing for maintaining and monitoring fish freshness[J].ACS Food Science & Technology, 2023, 3, 1366-1375.
21. Zhilang Xu, Die Yang, Tao Long, Lun Yuan, Shi Qiu, Defu Li, Changdao Mu,Liming Ge*.pH-Sensitive nanoparticles based on amphiphilic imidazole/cholesterol modified hydroxyethyl starch for tumor chemotherapy[J].Carbohydrate Polymers, 2022, 277: 118827.
20.葛黎明,徐錦芳,穆暢道,李德富*.雙醛纖維素納米晶Pickering乳液的制備及其釋放二氫楊梅素的研究[J].食品與發(fā)酵工業(yè), 2022, 48(23): 156-164.
19. Lun Yuan, Zijing Li, Xinying Li, Shi Qiu, Jinfeng Lei,* Defu Li, Changdao Mu,Liming Ge*. Functionalization of an injectable self-healing pH-responsive hydrogel by incorporating curcumin/polymerized β-CD inclusion complex for selective toxicity to osteosarcoma[J].ACS Applied Polymer Materials, 2022, 4(2): 1243-1254.
18. Hongmei Zhou, Lun Yuan, Zhilang Xu, Xueling Yi, Xiao Wu, Changdao Mu,Liming Ge*, Defu Li*. Mimicking the composition and structure of the osteochondral tissue to fabricate a heterogeneous three-layer scaffold for the repair of osteochondral defects[J].ACS Applied Bio Materials, 2022, 5(2), 734-746.
17. Zhilang Xu, Lun Yuan, Qisong Liu, Defu Li, Changdao Mu, Lei Zhao, Xinying Li*,Liming Ge*. Crosslinking effect of dialdehyde cholesterol modified starch nanoparticles on collagen hydrogel[J].Carbohydrate Polymers, 2022, 285: 119237.
16.Liming Ge, Zijing Li, Miao Han, Yongjie Wang, Xinying Li*, Changdao Mu, Defu Li*. Antibacterial dialdehyde sodium alginate/ε-polylysine microspheres for fruit preservation[J].Food Chemistry, 2022, 387: 132885.
15. Xueling Yi, Zhilang Xu, Qisong Liu, Hongmei Zhou, Lun Yuan, Defu Li, Lei Zhao, Changdao Mu,Liming Ge*. Matrix metalloproteinase-responsive collagen-oxidized hyaluronic acid injectable hydrogels for osteoarthritic therapy[J].Biomaterials Advances, 2022, 137: 212804.
14. Xiao Wu,Liming Ge*, Guohua Shen, Ying He, Zhilang Xu, Defu Li, Changdao Mu, Lei Zhao, Wenjie Zhang*.131I-Labeled silk fibroin microspheres for radioembolic therapy of rat hepatocellular carcinoma[J].ACS Applied Materials & Interfaces, 2022, 14(19): 21848-21859.
13. Die Yang, Shilong Yang, Mingze Mu, Xueping Liu, Lei Zhao, zhilang Xu, Changdao Mu, Defu Li*,Liming Ge*. Multifunctional β-cyclodextrin-polyethylene glycol-cholesterol nanomicelle for anti-cancer drug delivery[J].ACS Applied Bio Materials, 2022, 5(11): 5418-5431.
12. Keyan Miao, Xinying Li, Die Yang, Yongbin Xu, Changdao Mu, Defu Li,Liming Ge*. Hydrothermal shrinkage behavior of pigskin[J].Thermochimica Acta, 2021, 699: 178896.
11.李新瑩,繆可言,葛黎明*,李德富*.膠原蛋白熱變性檢測(cè)方法的比較研究[J].皮革科學(xué)與工程, 2021, 31(3): 41-45.
10. Jinfang Xu, Xinying Li, Yaqin Xu, Anqi Wang, Zhilang Xu, Xia Wu, Defu Li, Changdao Mu,Liming Ge*. Dihydromyricetin-loaded pickering emulsions stabilized by dialdehyde cellulose nanocrystals for preparation of antioxidant gelatin-based edible films[J].Food and Bioprocess Technology, 2021, 14: 1648-1661.
9. Lei Deng, Xinying Li, Keyan Miao, Xinyan Mao, Miao Han, Defu Li, Changdao Mu,Liming Ge*. Development of disulfide bond crosslinked gelatin/ε-polylysine active edible film with antibacterial and antioxidant activities[J].Food and Bioprocess Technology, 2020, 13(4): 577-588.
8. Xi Zhao, Xinying Li, Xiaofen Xie, Jinfeng Lei,Liming Ge*, Lun Yuan, Defu Li*, Changdao Mu. Controlling the pore structure of collagen sponge by adjusting the crosslinking degree for construction of heterogeneous double-layer bone barrier membrane[J].ACS Applied Bio Materials, 2020, 3(4): 2058-2067.
7. Xiaofen Xie, Xinying Li, Jinfeng Lei, Xi Zhao, Yongbo Lyu, Changdao Mu, Defu Li,Liming Ge*, Yongbin Xu*. Oxidized starch cross-linked porous collagen-based hydrogel for spontaneous agglomeration growth of adipose-derived stem cells[J].Materials Science and Engineering: C, 2020, 116: 111165.
6.韓淼,李德榮,袁柳青,呂永博,葛黎明*,李德富,穆暢道.雙醛淀粉還原制備納米銀及其在膠原基抗菌敷料中的應(yīng)用[J].高分子學(xué)報(bào), 2019, 50(4): 366-374.
5.Liming Ge, Yongbin Xu, Xinying Li, Lun Yuan, Huan Tan, Defu Li*, Changdao Mu. Fabrication of antibacterial collagen-based composite wound dressing[J].ACS Sustainable Chemistry & Engineering, 2018, 6(7), 9153-9166.
4.Liming Ge, Mingjin Zhu, Xinying Li, Yongbin Xu*, Xiaonan Ma, Rong Shi, Defu Li*, Changdao Mu. Development of active rosmarinic acid-gelatin biodegradable films with antioxidant and long-term antibacterial activities[J].Food Hydrocolloids, 2018, 83(10): 308-316.
3.Liming Ge, Mingjin Zhu, Yongbin Xu, Xinying Li*, Defu Li*, Changdao Mu. Development of antimicrobial and controlled biodegradable gelatin-based edible films containing nisin and amino-functionalized montmorillonite[J].Food and Bioprocess Technology, 2017, 10(9): 1727-1736.
2.Liming Ge, Yongbin Xu, Weijie Liang, Xinying Li*,Defu Li*, Changdao Mu. Short-range and long-range cross-linking effects of polygenipin on gelatin-based composite materials[J].Journal of Biomedical Materials Research Part A, 2016, 104(11): 2712-2722.
1.Liming Ge, Xinying Li, Run Zhang, Tianhan Yang, Xiaowei Ye, Defu Li*, Changdao Mu. Development and characterization of dialdehyde xanthan gum crosslinked gelatin based edible films incorporated with amino-functionalized montmorillonite[J].Food Hydrocolloids, 2015, 51(10): 129-135.
發(fā)明專利：
1.葛黎明,王琦,周慶,王踏秋,李德富,穆暢道,徐志朗.一種可溶性載藥微針及其制備方法.申請(qǐng)?zhí)? 202310046516.9.
2.葛黎明,廖偉棟,楊敏軒,李德富,穆暢道.一種納米氧化鋅/膠原基抗菌敷料及其制備方法.專利號(hào): ZL202110912392.9.
3.葛黎明,徐錦芳,陳沁菲,李德富,穆暢道.活性明膠基可食性膜及其制備與應(yīng)用方法.專利號(hào): ZL202110248712.5.
4.葛黎明,徐志朗,周昌海,王欣欣,楊麗可,周曉,李德富.一種雙醛多糖納米顆粒交聯(lián)膠原水凝膠及其制備方法.專利號(hào): ZL202010541765.1.
5.葛黎明,解曉芬,林先玉,李德富,穆暢道.一種具有促血管再生性能的膠原基細(xì)胞支架及其制備方法.專利號(hào): ZL201910460122.1.
獲得榮譽(yù)：
1.第十二屆全國(guó)大學(xué)生藥苑論壇“創(chuàng)新成果一等獎(jiǎng)”和“優(yōu)秀論文獎(jiǎng)”，指導(dǎo)教師
2.第六屆四川大學(xué)“互聯(lián)網(wǎng)+”大學(xué)生創(chuàng)新創(chuàng)業(yè)大賽三等獎(jiǎng)，指導(dǎo)教師
3.四川大學(xué)2019年大學(xué)生創(chuàng)新創(chuàng)業(yè)與實(shí)踐教育優(yōu)秀指導(dǎo)教師
4.全國(guó)大學(xué)生生命科學(xué)競(jìng)賽（2021，科學(xué)探究類）國(guó)賽三等獎(jiǎng)，指導(dǎo)教師
5.第八屆四川省大學(xué)生“生命之星”科技邀請(qǐng)賽二等獎(jiǎng)，指導(dǎo)教師
6.第九屆四川省大學(xué)生“生命之星”科技邀請(qǐng)賽二等獎(jiǎng)，指導(dǎo)教師
7.全國(guó)大學(xué)生生命科學(xué)競(jìng)賽（2022，科學(xué)探究類）國(guó)賽三等獎(jiǎng)，指導(dǎo)教師
8.四川大學(xué)2021年大學(xué)生創(chuàng)新創(chuàng)業(yè)與實(shí)踐教育優(yōu)秀指導(dǎo)教師
9.第二屆四川省大學(xué)生“生命之星”科技競(jìng)賽省級(jí)三等獎(jiǎng)，指導(dǎo)教師
社會(huì)兼職：
擔(dān)任四川省皮革學(xué)會(huì)理事，中國(guó)化工學(xué)會(huì)會(huì)員，中國(guó)生物材料學(xué)會(huì)會(huì)員，以及擔(dān)任Advanced Science，Advanced Healthcare Materials，Advanced Fiber Materials，ACS Applied Materials & Interfaces，Biomacromolecules，Carbohydrate Polymers，International Journal of Biological Macromolecules等國(guó)際期刊審稿人。
