黃文才 副教授
四川大學(xué)beat365制藥與生物工程系
聯(lián)系方式：成都市一環(huán)路南一段24號(hào)四川大學(xué)beat365（郵編610065）
E-mail: hwc@scu.edu.cn
教育背景
1993. 9 -- 1997. 7成都科技大學(xué)有機(jī)化工專業(yè)工學(xué)學(xué)士
1997. 9 -- 2000. 7四川大學(xué)應(yīng)用化學(xué)專業(yè)工學(xué)碩士
2000. 9 -- 2003. 7四川大學(xué)藥物化學(xué)專業(yè)理學(xué)博士
工作簡(jiǎn)歷
2003. 9 -- 2005. 9中科院上海藥物研究所博士后
2005. 10 --至今四川大學(xué)beat365制藥與生物工程系講師/副教授/碩士生導(dǎo)師
2014. 9 -- 2015. 9美國弗吉尼亞大學(xué)化學(xué)系訪問學(xué)者
教學(xué)工作
負(fù)責(zé)本科生《藥物化學(xué)》、《化學(xué)制藥工藝學(xué)》及研究生《藥品制造工程導(dǎo)論》等課程的教學(xué)工作，主編《藥物合成反應(yīng)》（科學(xué)出版社，2021），副主編《制藥工程技術(shù)概論》（化工出版社，2019）。
科研方向
1.小分子熒光探針的研究
2.藥物研制與開發(fā)
3.綠色化學(xué)制藥工藝研究
主持或參加國家自然科學(xué)基金、廣東省-教育部產(chǎn)學(xué)研結(jié)合項(xiàng)目、四川大學(xué)校青年科研基金及多項(xiàng)企業(yè)合作開發(fā)項(xiàng)目。
代表性科研成果
1.Zhang Dan, Wang Sifan, Yang Fangxi, Qi Qingrong, Li Yanfang*,Huang Wencai*. A fluorescent probe for alkylating agents and its quantification of triflate as a genotoxic impurity. Chem. Commun., 2023,59(15): 2130-2133.
2.Zhang Dan, Wang Sifan, Yang Fangxi, Li Zicheng,Huang Wencai*. Visual inspection of acidic pH and bisulfite in white wine using a colorimetric and fluorescent probe. Food Chem.. 2023,408: 135200.
3.Zhang Zichang, Zhang Dan, Qi Qingrong, Li Zicheng,Huang Wencai*. A colorimetric and fluorometric probe for phenylhydrazine and its application in real samples. Chem. Commun., 2022,58(61): 8540-8543.
4.Zhang Zichang, Tu Liangping, Zhang Dan, Li Zicheng,Huang Wencai*. Comparative studies on the absorption and fluorescence responses of hemicyanine to HSO3-, CN-, HS-and ClO-. Spectrochim. Acta A, 2022,269: 120781.
5.Tu Liangping, Liu Jian, Zhang Zichang, Qi Qingrong, Yao Shun,Huang Wencai*. Micheal addition reaction-based fluorescent probe for malononitrile detection and its applications in aqueous solution, living cells and zebrafish. Analyst,2021,146(7): 2221-2228.
6.Wang Shun, Liu Jian,Song Linjiang, Qi Qingrong*, Li Zicheng, Huang Wencai*.A selective and sensitive near-infrared fluorescent probe for in vivo real time tracking of exogenous and metabolized hydrazine, a genotoxic impurity. J. Mater. Chem. B, 2020,8(45): 10353-10359.
7.Zhang Yi, Tu Liangping, Lu Lingling, Li Yuxiao, Song Linjiang,* Qi Qingrong, Song Hang, Li Zicheng,Huang Wencai*.Screening and application of boron difluoride complex of curcumin as a colorimetric and ratiometric fluorescent probe for bisulfite. Anal. Methods, 2020,12(11): 1514-1521.
8.Liu Jian, Li Tao, Wang Shun, Qi Qingrong, Song Hang, Li Zicheng, Yang Li*,Huang Wencai*. A sensitive and selective fluorescent probe for hydrazine with a unique nonaromatic fluorophore. RSC Adv.,2020,10: 5572-5578.
9.Li Tao, Liu Jian, Song Linjiang, Li Zicheng, Qi, Qingrong*,Huang Wencai*. A hemicyanine-based fluorescent probe for hydrazine detection in aqueous solution and its application in real time bioimaging of hydrazine as a metabolite in mice. J. Mater. Chem. B, 2019,7: 3197-3200.
10.Li Yuan, Ji Yu-Xin, Song Lin-Jiang, Zhang Yi, Li Zi-Cheng, Yang Li,Huang Wen-Cai*. A novel BF2-curcumin-based fluorescent chemosensor for detection of Cu2+in aqueous solution and living cells. Res. Chem. Intermed., 2018,44(9): 5169-5180.
11.Zhou Ji-Cai, Zhao Lei, Li Yuan, Fu Ding-Qiang, Li Zi-Cheng,Huang Wen-Cai*. Alkynylation of aldehydes mediated by Zinc and allyl bromide: a practical synthesis of propargylic alcohols. Res. Chem. Intermed., 2017,43(7):4283-4294.
12.Zhang Yun-Hao, Wu Ming-Yue,Huang Wen-Cai*. Silica gel-promoted practical synthesis of oxindole-nitrones from diazooxindoles and nitrosoarenes under solvent-free conditions. RSC Adv., 2015,5(128): 105825-105828.
13.Huang Wen-Cai, Liu Winnie, Wu Xue-Dan, Ying Jun, Pu Lin*. Highly enantioselective alkyne addition to aliphatic, aromatic and vinyl aldehydes by using Zn,iPrI, H8BINOL and Ti(OiPr)4. J. Org. Chem., 2015,80(22): 11480-11484.
14.Xie J. Y., Liu J. Q., Zhang Y. H., Li J. J., Li Z. C.,Huang W. C.*. An improved preparation of 2, 6-di-tert-butyl-4-methylphenol. Org. Prep. Proced. Int., 2015,47(3): 236-241.
15.Liu Junqiang, Mi Chenggen, Tang Xuemei, Cao Yuan, Li Zicheng,Huang Wencai*. Facilemicrowave-assisted synthesis of substituted benzofuran derivatives. Res. Chem. Intermed., 2014,40(5): 2083-2090.
16.Yang Li, Lei Hua, Mi Cheng-Gen, Liu Huan, Zhou Tian, Zhao Ying-Lan, Lai Xiao-Yun, Li Zi-Cheng, Song Hang,Huang Wen-Cai*. Synthesis, antiproliferative activities and in vitro biological evaluation of novel benzofuransulfonamide derivatives. Bioorg. Med. Chem. Lett., 2011,21(18): 5389-5392.
17.Luo Xin-Feng, He Ling, Yin Hai-Bin, Zheng Hu, Bei Di, Deng Jin-Jin,Huang Wen-Cai*. Efficient acylation and one-pot synthesis of dehydroandrographolide succinate on a large scale assisted with microwave radiation. Synth. Commun., 2009,39(19): 3444-3452.
18.Huang Wencai, Zheng Hu, Weng Lingling. Synthesis of tetracycline analogs and their bone affinities. Chin. Chem. Lett., 2008,19(1): 19-22.
19.黃文才,張丹,程度,張春紅,陳文芝,雷華.一種三水合3-氨基丙基胺乙基硫代磷酸的合成方法.中國發(fā)明專利, ZL 201110152336.6, 2014-2-26.
